Panel one: stick figures are fine, as long as the format is preserved context clues will let people know what you are doing.
Panel two: we can't deviate too far from the original or it stops being the same meme.
Panel three: variation on the idea is the point of a meme, the name intentionally paralleled genes.
Panel four: That original context is all but lost to most further proving my point.
Panel five: how is this self referential humor recognizable then?
when I was about 5 years old, my grandfather who's a carpenter sent me to the garage to find his square so he could measure something. I happily agreed, and then went and looked for so long, but despite my best efforts, I couldn't find anything square shaped. I lost my mind when he came in after wondering what was taking so long and said "what do you mean you couldn't find it? it's right here" then proceeded to pick up what is most definitely a triangle.